The Kafue is one of the largest National Parks in Africa and also one of its least explored wild regions. The park is world-famous for its animals, especially its wealth of antelope species. The Kafue has the greatest diversity of wildlife of any national park in Africa due to its huge size and range of habitats. The habitats are so varied and unique it can be thought of as several separate, smaller parks. 

The Kafue River is a lifeblood for the Park and offers good game viewing in several areas it runs through. The best game viewing in the Kafue is the Busanga Plains on the parks North. The Lufupa River fills the Busanga Swamp which seasonally floods the fertile grasslands of the Busanga Plains. The rich soil and surface water make this area a haven for wildlife. Huge herds of red lechwe – in the thousands are found, as well as puku, greater kudu, oribi and waterbuck. It is also renowned for frequent sightings of lion, leopard and cheetah. The south of the park receives greater rainfall and thus has more established flora with higher vegetation and some lovely forested areas. The Kafue River and its tributaries themselves are a focus for wildlife, with large pods of hippopotamuses, herds of elephants and some of the largest crocodiles in Africa.